Background Transcranial direct current stimulation has shown promising clinical results,
leading to increased demand for an evidence-based review on its clinical effects. Objective …

Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

Synaptic loss and deficits in functional connectivity are hypothesized to contribute to
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …

The coexistence of immune-mediated inflammatory diseases with depression has long been
recognised. Data that illustrate the intimate associations between peripheral and brain …

Adverse childhood experiences (ACEs) may leave long-lasting neurobiological scars,
increasing the risk of developing mental disorders in later life. However, no review has …

Depression is the leading cause of disability around the world, but little is known about its
pathology. Currently, the diagnosis of depression is made based on clinical manifestations …

Activity-dependent synaptic plasticity is a ubiquitous property of the nervous system that
allows neurons to communicate and change their connections as a function of past …

Importance Psychiatric diagnoses are currently distinguished based on sets of specific
symptoms. However, genetic and clinical analyses find similarities across a wide variety of …

The prevalence, age of onset, and symptomatology of many neuropsychiatric conditions
differ between males and females. To understand the causes and consequences of sex …