Oxysterol-binding protein (OSBP) and OSBP-related proteins (ORPs) constitute one of the
largest families of lipid-binding/transfer proteins (LTPs) in eukaryotes. The current view is …

Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at
membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's …

Oxysterol binding protein (OSBP) extracts cholesterol from the ER to deliver it to the TGN via
counter exchange and subsequent hydrolysis of the phosphoinositide PI (4) P. Here, we …

The three-dimensional (3D) tumor spheroid model is a critical tool for high-throughput
ovarian cancer research and anticancer drug development in vitro. However, the 3D …

Disease recurrence in high-grade serous ovarian cancer may be due to cancer stem–like
cells (CSC) that are resistant to chemotherapy and capable of reestablishing heterogeneous …

OSW-1, a steroidal saponin isolated from the bulbs of Ornithogalum saundersiae, is a
promising compound for an anticancer drug; however, its cytotoxic mechanisms have not …

Oxysterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4) have emerged as
potentially druggable targets in antiviral and precision cancer drug development. Multiple …

Simple Summary A selected set of natural products that target the structure and function of
the Golgi apparatus in cancer cells is highlighted in this review. The potential for modulating …

Intracellular sterol transport proteins (STPs) are crucial for maintaining cellular lipid
homeostasis by regulating local sterol pools. Despite structural similarities in their sterol …

Background: Gliomas are the most common primary intracranial malignant tumors with poor
prognosis, despite the remarkable advances in medical technology that have been made …