The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly
understood. In this far-reaching review, we examine what is currently known about ALS …

Mutations in superoxide dismutase 1 gene (SOD1) are linked to amyotrophic lateral
sclerosis (ALS), a neurodegenerative disorder predominantly affecting upper and lower …

Although clinical picture of amyotrophic lateral sclerosis (ALS) is a stereotypical one,
resulting from combination of signs secondary to dysfunction of both upper motor neuron …

Patients with amyotrophic lateral sclerosis (ALS) often have questions about why they
developed the disease and the likelihood that family members will also be affected. In recent …

In amyotrophic lateral sclerosis (ALS) patients with known genetic cause, mutations in
chromosome 9 open reading frame 72 (C9orf72) and superoxide dismutase 1 (SOD1) …

Background and objectives Amyotrophic lateral sclerosis associated with mutations in SOD1
(SOD1-ALS) might be susceptible to specific treatment. The aim of the study is to outline the …

Although mutations in the superoxide dismutase 1 gene account for only a minority of total
amyotrophic lateral sclerosis cases, the discovery of this gene has been crucial for …

Background SOD1 mutations are the most common cause of amyotrophic lateral sclerosis
(ALS) in non-Caucasian patients. Detailed natural history profiles of SOD1-mutant patients …

Ten years ago, commercial genetic testing for amyotrophic lateral sclerosis (ALS) was
limited to SOD1 sequencing, while only MAPT and GRN sequencing was available for …

Background Uncovering distinct features and trajectories of amyotrophic lateral sclerosis
(ALS) associated with SOD1 mutations (SOD1-ALS) can provide valuable insights for …