Studying the human immune system is challenging. These challenges stem from the
complexity of the immune system itself, the heterogeneity of the immune system between …

Chronic or recurrent episodes of acute inflammation cause attrition of normal hematopoietic
stem cells (HSCs) that can lead to hematopoietic failure but they drive progression in …

Importance Psoriasis is a common autoinflammatory disease influenced by complex
interactions between environmental and genetic factors. The influence of long-term air …

Autoimmune diseases (ADs) have a common pathophysiological mechanism as a
consequence of sharing genetic and environmental factors, as well as similar clinical …

Patients with Immune-Mediated Inflammatory Diseases (IMIDs) are known to have an
elevated risk of developing cancer, but the exact causative factors remain subject to ongoing …

Population-scale single-cell genomics is a transformative approach for unraveling the
intricate links between genetic and cellular variation. This approach is facilitated by cutting …

Polygenic scores estimate genetic susceptibility to diseases. We systematically calculated
polygenic scores across 457 phenotypes using genotyping array data from China Medical …

Inborn errors of immunity (IEI) comprise a diverse spectrum of 485 disorders as recognized
by the International Union of Immunological Societies Committee on Inborn Error of …

Background Childhood-onset lupus nephritis (cLN) is a severe form of systemic lupus
erythematosus (SLE) with high morbidity and mortality. The impact of long-term exposure to …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with intricate pathogenesis
and varied presentation. Accurate diagnostic tools are imperative to detect and manage UC …