Metabolites are the small biological molecules involved in energy conversion and
biosynthesis. Studying metabolism is inherently challenging due to metabolites' reactivity …

Synthesizing trait observations and knowledge across the Tree of Life remains a grand
challenge for biodiversity science. Species traits are widely used in ecological and …

The global rise in obesity has revitalized a search for genetic and epigenetic factors
underlying the disease. We present a Drosophila model of paternal-diet-induced …

Animals must adapt their dietary choices to meet their nutritional needs. How these needs
are detected and translated into nutrient-specific appetites that drive food-choice behaviours …

Carbohydrate metabolism is essential for cellular energy balance as well as for the
biosynthesis of new cellular building blocks. As animal nutrient intake displays temporal …

INTRODUCTION To accommodate daily and seasonal variation in caloric intake, metazoans
have evolved specialized tissues dedicated to dynamic storage and release of energy …

Obesity caused by genetic and environmental factors can lead to compromised skeletal
muscle function. Time-restricted feeding (TRF) has been shown to prevent muscle function …

The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the
secretion of glucagon and insulins in mammals. Although glucagon-like and insulin-like …

Maintenance of biological functions under negative energy balance depends on
mobilization of storage lipids and carbohydrates in animals. In mammals, glucagon and …

Control of insulin mRNA translation is crucial for energy homeostasis, but the mechanisms
remain largely unknown. We discovered that insulin mRNAs across invertebrates …