ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …

APOE4 is the strongest genetic risk factor for late-onset Alzheimer disease. ApoE4 increases
brain amyloid-β pathology relative to other ApoE isoforms. However, whether APOE …

Alzheimer disease is more than a pure proteopathy. Chronic neuroinflammation stands out
during the pathogenesis of the disease and in turn modulates disease progression. The …

Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …

The ɛ4 allele of the apolipoprotein E gene (APOE), which translates to the APOE4 isoform,
is the strongest genetic risk factor for late-onset Alzheimer disease (AD). Within the CNS …

Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand
for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and …

Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …

ApoE on high-density lipoproteins is primarily responsible for lipid transport and cholesterol
homeostasis in the central nervous system (CNS). Normally produced mostly by astrocytes …

Genome-wide association studies (GWAS) have identified the PICALM (Phosphatidylinositol
binding clathrin-assembly protein) gene as the most significant genetic susceptibility locus …