Melatonin is a fascinating molecule that has captured the imagination of many scientists
since its discovery in 1958. In recent times, the focus has changed from investigating its …

Cerebral ischemia-reperfusion (I/R) injury is the predominant causes for the poor prognosis
of ischemic stroke patients after reperfusion therapy. Currently, potent therapeutic …

Mitochondrial dysfunction is a key event in many pathological conditions, including
neurodegenerative processes. When mitochondria are damaged, they release damage …

Tau hyper-phosphorylation has been recognized as an essential contributor to
neurodegeneration in Alzheimer's disease (AD) and related tauopathies. In the last decade …

The Notch1 signaling pathway plays a crucial role in the development of the central nervous
system, governing pivotal functional activities in the brain, such as neurogenesis. Sirt3 is …

Wilson disease (WD) is a severely autosomal genetic disorder triggered by dysregulated
copper metabolism. Autophagy and apoptosis share common modulators that process …

Abstract Mono-2-ethylhexyl phthalic acid (MEHP) is the most toxic metabolite of the
plasticizer di-2-ethylhexyl phthalic acid (DEHP), and studies have shown that MEHP causes …

Sevoflurane (Sev) is a commonly used inhalation anaesthetic that has been shown to cause
hippocampus dysfunction through multiple underlying molecular processes, including …

Melatonin is a phylogenetically ancient molecule with diverse biological activities, including
anti-inflammatory and redox properties. Although its role as an antioxidant is well …

缺血再灌注(ischemia-reperfusion, I/R) 作为一种复杂血流动力学过程, 可通过氧化应激,
线粒体功能障碍和炎症反应等引起组织损伤, 是导致患者预后不良的重要因素 …