Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

One of the central questions in neuroscience is how particular tasks, or computations, are
implemented by neural networks to generate behavior. The prevailing view has been that …

The biophysical features of neurons shape information processing in the brain. Cortical
neurons are larger in humans than in other species, but it is unclear how their size affects …

The vast computational power of the brain has traditionally been viewed as arising from the
complex connectivity of neural networks, in which an individual neuron acts as a simple …

Dendrites are the main recipients of synaptic inputs and are important sites that determine
neurons' input-output functions. This review focuses on thin neocortical dendrites, which …

Most synaptic inputs are made onto the dendritic tree. Recent work has shown that dendrites
play an active role in transforming synaptic input into neuronal output and in defining the …

Transforming synaptic input into action potential output is a fundamental function of neurons.
The pattern of action potential output from principal cells of the mammalian hippocampus …

The highly interconnected local and large-scale networks of the neocortical sheet rapidly
and dynamically modulate their functional connectivity according to behavioral demands …

The dendrites of neocortical pyramidal neurons are excitable. However, it is unknown how
synaptic inputs engage nonlinear dendritic mechanisms during sensory processing in vivo …

The thick-tufted layer 5 (TTL5) pyramidal neuron is one of the most extensively studied
neuron types in the mammalian neocortex and has become a benchmark for understanding …