In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Caspases are a family of endoproteases that provide critical links in cell regulatory networks
controlling inflammation and cell death. The activation of these enzymes is tightly controlled …

SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

Metabolic activity is a crucial determinant of a cell's decision to proliferate or die. Although it
is not fully understood how metabolic pathways such as glycolysis and the pentose …

Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family
and has been implicated in both apoptotic and non-apoptotic signaling pathways, including …

Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage
targets are poorly understood. Caspase-2 is activated by the p53 target gene product PIDD …

For single-cell organisms, nutrient uptake and metabolism are central to the fundamental
decision of whether to grow or divide. In metazoans, cell fate decisions are more complex …

Aberrations in proteins that control apoptosis and cell survival are common in cancer. These
aberrations often reside in signalling proteins that control the activation of the apoptotic …

Increasing evidence points to the functional importance of alternative splice variations in
cancer pathophysiology. Two splice variants are derived from the CASP9 gene via the …

Targeting oncogenic microRNAs (miRNAs) is emerging as a promising strategy for cancer
therapy. In this study, we provide proof of principle for the safety and efficacy of miRNA …