Lymphangiogenesis refers to the generation of new lymphatic vessels from pre-existing
ones. During development and particular adult states, lymphatic endothelial cells (LEC) …

The lymphatic vascular system acts as the major transportation highway of tissue fluids, and
its activation or impairment is associated with a wide range of diseases. There has been …

Aims Histone H3 dimethylation at lysine 79 is a key epigenetic mark uniquely induced by
methyltransferase disruptor of telomeric silencing 1-like (DOT1L). We aimed to determine …

The central nervous system (CNS) is considered as an immune privilege organ, based on
experiments in the mid 20th century showing that the brain fails to mount an efficient immune …

The lymphatic system is crucial for the maintenance of interstitial fluid and protein
homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked …

DOT1-Like (DOT1L) is the sole methyltransferase of histone H3K79, a modification enriched
mainly on the bodies of actively transcribing genes. DOT1L has been extensively studied in …

Tissue nanotransfection (TNT) topically delivers Etv2, Foxc2, and Fli1 (EFF) plasmids
increasing vasculogenic fibroblasts (VF) and promoting vascularization in ischemic murine …

Background: The chromatin-remodeling enzyme BRG1 (brahma-related gene 1) regulates
gene expression in a variety of rapidly differentiating cells during embryonic development …

Epigenetic mechanisms are mandatory for endothelial called lymphangioblasts during
cardiovascular development. Dot1l-mediated gene transcription in mice is essential for the …

Non-alcoholic fatty liver disease (NAFLD) poses a significant health challenge in modern
societies due to shifts in lifestyle and dietary habits. Its complexity stems from genetic …