Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily
broad set of functional roles. Central among these roles are the promotion of …

The infection of mammalian cells by viruses and innate immune responses to infection are
spatiotemporally organized processes. Cytosolic RNA sensors trigger nuclear translocation …

Virus recognition and response by the innate immune system are critical components of host
defense against infection. Activation of cell-intrinsic immunity and optimal priming of …

RNA helicase DHX9 has been extensively characterized as a transcriptional regulator,
which is consistent with its mostly nucleic localization. It is also involved in recognizing RNA …

In eukaryotic organisms, the orthologs of the DEAD-box RNA helicase Ded1p from yeast
and DDX3 from human form a well-defined subfamily that is characterized by high sequence …

Abstract DEAD/H-box RNA helicases make the prominent family of helicases super family-2
which take part in almost all RNA-related processes, from initiation of transcription to RNA …

RNA-binding proteins (RBPs) are effectors and regulators of posttranscriptional gene
regulation (PTGR). RBPs regulate stability, maturation, and turnover of all RNAs, often …

DExH/D-box helicases are essential nucleic acid and ribonucleoprotein remodelers
involved in all aspects of nucleic acid metabolism including replication, gene expression …

RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA
viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another …