Strategic approaches to improvise peptide drugs as next generation therapeutics

P Barman, S Joshi, S Sharma, S Preet… - International journal of …, 2023 - Springer
In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an
increase in interest in alternate therapies. Peptide-based drugs as an alternate therapy hold …

RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

U Hersel, C Dahmen, H Kessler - Biomaterials, 2003 - Elsevier
Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote
cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small …

Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine

K He, T Wan, D Wang, J Hu, T Zhou, W Tao, Z Wei… - Cell, 2023 - cell.com
The intestinal epithelial cells (IECs) constitute the primary barrier between host cells and
numerous foreign antigens; it is unclear how IECs induce the protective immunity against …

A decade of caspases

A Degterev, M Boyce, J Yuan - Oncogene, 2003 - nature.com
Caspases are a family of cysteine proteases that play important roles in regulating
apoptosis. A decade of research has generated a wealth of information on the signal …

Caspase structure, proteolytic substrates, and function during apoptotic cell death

DW Nicholson - Cell Death & Differentiation, 1999 - nature.com
Caspases play an essential role during apoptotic cell death. These enzymes define a new
class of cysteine proteases and comprise a multi-gene family with more than a dozen distinct …

Proteases for cell suicide: functions and regulation of caspases

HY Chang, X Yang - Microbiology and molecular biology reviews, 2000 - Am Soc Microbiol
Caspases are a large family of evolutionarily conserved proteases found from
Caenorhabditis elegans to humans. Although the first caspase was identified as a …

Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation

AW Griffioen, G Molema - Pharmacological reviews, 2000 - ASPET
Angiogenesis, or the formation of new blood vessels out of pre-existing capillaries, is a
sequence of events that is fundamental to many physiologic and pathologic processes such …

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

MA Karsdal, T Manon-Jensen… - American Journal …, 2015 - journals.physiology.org
Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Anticancer peptides mechanisms, simple and complex

P Norouzi, M Mirmohammadi, MHH Tehrani - Chemico-Biological …, 2022 - Elsevier
Peptide therapy has started since 1920s with the advent of insulin application, and now it
has emerged as a new approach in treatment of diseases including cancer. Using anti …

Tissue engineering: a new paradigm for periodontal regeneration based on molecular and cell biology.

PM Bartold, CAG Mcculloch… - Periodontology …, 2000 - search.ebscohost.com
Focuses on tissue engineering as paradigm for periodontal regeneration based on
molecular and cell biology. Reestablishment of soft tissue attachment on root surface; …