Modulators of microglial activation and polarization after intracerebral haemorrhage

X Lan, X Han, Q Li, QW Yang, J Wang - Nature Reviews Neurology, 2017 - nature.com
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

J Xu, Z Chen, F Yu, H Liu, C Ma, D Xie… - Proceedings of the …, 2020 - National Acad Sciences
Intracerebral hemorrhage (ICH) is a devastating form of stroke affecting millions of people
worldwide. Parenchymal hematoma triggers a series of reactions leading to primary and …

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

Z Zhang, YU Wu, S Yuan, P Zhang, J Zhang, H Li, X Li… - Brain research, 2018 - Elsevier
Oxidative stress plays an important role in secondary brain injury (SBI) after intracerebral
hemorrhage (ICH), but the underling mechanism has not been fully elucidated. Recently, the …

Neuroinflammation after intracerebral hemorrhage

E Mracsko, R Veltkamp - Frontiers in cellular neuroscience, 2014 - frontiersin.org
Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which
no specific treatment has been established yet. Although preclinical models of ICH have …

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

T Yang, Y Sun, Z Lu, RK Leak, F Zhang - Ageing research reviews, 2017 - Elsevier
As human life expectancy rises, the aged population will increase. Aging is accompanied by
changes in tissue structure, often resulting in functional decline. For example, aging within …

Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood–brain barrier in a mice hemorrhage model

A Manaenko, H Chen, J Kammer, JH Zhang… - Journal of neuroscience …, 2011 - Elsevier
AIMS: Intracerebral hemorrhage is one of the most devastating subtypes of stroke, leaving
survivors with severe neurological deficits. Disruption of the blood brain barrier (BBB) …

Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage

WB Rolland, T Lekic, PR Krafft, Y Hasegawa… - Experimental …, 2013 - Elsevier
T-lymphocytes promote cerebral inflammation, thus aggravating neuronal injury after stroke.
Fingolimod, a sphingosine 1-phosphate receptor analog, prevents the egress of …

Toll-like receptor 4 antagonist attenuates intracerebral hemorrhage–induced brain injury

YC Wang, PF Wang, H Fang, J Chen, XY Xiong… - Stroke, 2013 - Am Heart Assoc
Background and Purpose—Accumulating evidence indicates that inflammatory responses
cause secondary injury after intracerebral hemorrhage (ICH). We recently demonstrated the …

3D transcranial ultrasound localization microscopy for discrimination between ischemic and hemorrhagic stroke in early phase

A Chavignon, V Hingot, C Orset, D Vivien… - Scientific Reports, 2022 - nature.com
Early diagnosis is a critical part of the emergency care of cerebral hemorrhages and
ischemia. A rapid and accurate diagnosis of strokes reduces the delays to appropriate …