A concise tutorial review of TOF-SIMS based molecular and cellular imaging

P Massonnet, RMA Heeren - Journal of Analytical Atomic Spectrometry, 2019 - pubs.rsc.org
This concise tutorial review provides a description of the current state of the art in the
application of time-of flight based secondary ion mass spectrometry (TOF-SIMS) in the field …

Large cluster ions: soft local probes and tools for organic and bio surfaces

A Delcorte, V Delmez, C Dupont-Gillain… - Physical Chemistry …, 2020 - pubs.rsc.org
Ionised cluster beams have been produced and employed for thin film deposition and
surface processing for half a century. In the last two decades, kiloelectronvolt cluster ions …

Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry

AFM Altelaar, I Klinkert, K Jalink… - Analytical …, 2006 - ACS Publications
Surface metallization by plasma coating enhances desorption/ionization of membrane
components such as lipids and sterols in imaging time-of-flight secondary ion mass …

Low energy ion scattering (LEIS). A practical introduction to its theory, instrumentation, and applications

CV Cushman, P Brüner, J Zakel, GH Major… - Analytical …, 2016 - pubs.rsc.org
Low energy ion scattering (LEIS) probes the elemental composition of the outermost atomic
layer of a material and provides static depth profiles of the outer ca. 10 nm of surfaces. Its …

Colloidal Graphite-Assisted Laser Desorption/Ionization Mass Spectrometry and MSn of Small Molecules. 1. Imaging of Cerebrosides Directly from Rat Brain Tissue

S Cha, ES Yeung - Analytical chemistry, 2007 - ACS Publications
Graphite-assisted laser desorption/ionization (GALDI) mass spectrometry (MS) was
investigated for analysis of cerebrosides in a complex total brain lipid extract. Conventional …

Molecular depth profiling with cluster ion beams

J Cheng, A Wucher, N Winograd - The Journal of Physical …, 2006 - ACS Publications
Peptide-doped trehalose thin films have been characterized by bombardment with energetic
cluster ion beams of C60+ and Au x+(x= 1, 2, 3). The aim of these studies is to acquire …

Subcellular imaging mass spectrometry of brain tissue

LA McDonnell, SR Piersma… - Journal of mass …, 2005 - Wiley Online Library
Imaging mass spectrometry provides both chemical information and the spatial distribution
of each analyte detected. Here it is demonstrated how imaging mass spectrometry of tissue …

Sodium-doped gold-assisted laser desorption ionization for enhanced imaging mass spectrometry of triacylglycerols from thin tissue sections

M Dufresne, JF Masson, P Chaurand - Analytical chemistry, 2016 - ACS Publications
The deposition of sodium salts followed by a sputtered layer of gold has been demonstrated
to be a power combination for the analysis of triacylglycerols (TAGs) from tissue sections by …

[HTML][HTML] Surface characterization of polymer blends by XPS and ToF-SIMS

CM Chan, LT Weng - Materials, 2016 - mdpi.com
The surface properties of polymer blends are important for many industrial applications. The
physical and chemical properties at the surface of polymer blends can be drastically different …

Bioimaging TOF‐SIMS: Localization of cholesterol in rat kidney sections

H Nygren, P Malmberg, C Kriegeskotte… - Febs …, 2004 - Wiley Online Library
Rat kidneys were sectioned by cryoultramicrotomy and dried at room temperature. The
samples were covered with a thin silver layer and analyzed in an imaging TOF‐SIMS …