The weak and short-lasting biological activity of enkephalins can be ascribed to their rapid
metabolism. Three types of well defined peptidase activities in CNS may account for the …

John T. Gafford, Randal A. Skidgel, Ervin G. Erdos,* and Louis B. Hersh abstract: After
extracting converting enzyme from a mem-brane fraction of homogenized human …

The opioid peptides methionine-enkephalin and leucine-enkephalin appear to exert their
biological effects through a receptor mediated mechanism. There appears to be three …

The neutral endopeptidase EC 3.4. 24.11, also designated enkephalinase, has been
visualized by in vitro autoradiography using the tritiated inhibitor [3H]-N-[(2RS)-3 …

Utilizing the mouse tail-flick assay, the rank order of analgesic potency for various opioids
(icv) is β h 2-endorphin> D-Ala 2-D-Leu 5 eenkephalin> morphine> D-Ala 2-met …

Photoactivatable drugs and peptides can drive quantitative studies into receptor signaling
with high spatiotemporal precision, yet few are compatible with behavioral studies in …

The property of solutions of Triton X-114 to separate into detergent-rich and detergent-poor
phases at 30 degrees C has been exploited to investigate the identities of the …

We have examined enkephalin degradation by solubilized membrane fractions of rat brain.
Three distinct enkephalin degrading activities can be partially purified and …

An aminopeptidase from bovine brain which catalyzes the hydrolysis of the tyrosyl1‐
glycine2 bond of methionine5‐enkephalin has been purified to electrophoretic homogeneity …

Thymopoietin32–36 (TP5) is a synthetic pentapeptide that has the biological activity of its
parent molecule, the 49 amino acid thymic hormone thymopoietin. Tritiated thymopoietin32 …