Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral
response to replicate and propagate to new hosts. The complex regulation of the IFN …

Innate immune cells have complex signalling pathways for sensing pathogens and initiating
innate immune responses against infection. These pathways are tightly regulated at different …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS) detects
intracellular DNA and signals through the adapter protein STING to initiate the antiviral …

The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million
confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August …

Type I interferons (IFNs) play essential roles in establishing and modulating host defense
against microbial infection via induction of IFN-stimulated genes (ISGs) through Janus …

Abstract Type I interferons (IFN-Is) are a very important group of cytokines that are produced
by innate immune cells but also act on adaptive immune cells. IFN-Is possess antiviral …

Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have emerged since the start of the COVID-19 pandemic. Over this period, we developed …

Detection of intracellular DNA by the cGAS-STING pathway activates a type I interferon-
mediated innate immune response that protects from virus infection. Whether there are …