Design of virus-based nanomaterials for medicine, biotechnology, and energy

AM Wen, NF Steinmetz - Chemical Society Reviews, 2016 - pubs.rsc.org
This review provides an overview of recent developments in “chemical virology.” Viruses, as
materials, provide unique nanoscale scaffolds that have relevance in chemical biology and …

Virus-like nanoparticles as a novel delivery tool in gene therapy

J Jeevanandam, K Pal, MK Danquah - Biochimie, 2019 - Elsevier
Viruses are considered as natural nanomaterials as they are in the size range of 20–500 nm
with a genetical material either DNA or RNA, which is surrounded by a protein coat capsid …

Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers

S Shukla, JT Myers, SE Woods, X Gong, AE Czapar… - Biomaterials, 2017 - Elsevier
Cancer vaccines are designed to elicit an endogenous adaptive immune response that can
successfully recognize and eliminate residual or recurring tumors. Such approaches can …

POxylation as an alternative stealth coating for biomedical applications

H Bludau, AE Czapar, AS Pitek, S Shukla… - European polymer …, 2017 - Elsevier
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to
reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its …

Cowpea mosaic virus promotes anti‐tumor activity and immune memory in a mouse ovarian tumor model

C Wang, SN Fiering, NF Steinmetz - Advanced therapeutics, 2019 - Wiley Online Library
Cowpea mosaic virus (CPMV) is a promising platform nanotechnology with applications as a
cancer therapeutic. To understand the therapeutic potential of CPMV in more detail, its …

Cellular fate of a plant virus immunotherapy candidate

AO Omole, JF Affonso de Oliveira, L Sutorus… - Communications …, 2024 - nature.com
Cowpea mosaic virus (CPMV) is a plant virus that is currently being developed for
intratumoral immunotherapy. CPMV relieves the immune system from tumor-induced …

The pharmacology of plant virus nanoparticles

CI Nkanga, NF Steinmetz - Virology, 2021 - Elsevier
The application of nanoparticles for medical purposes has made enormous strides in
providing new solutions to health problems. The observation that plant virus-based …

CD47 blockade and cowpea mosaic virus nanoparticle in situ vaccination triggers phagocytosis and tumor killing

C Wang, NF Steinmetz - Advanced healthcare materials, 2019 - Wiley Online Library
Contemporary immunotherapies, eg, those that target the CTLA‐4 and PD‐1/PD‐L1 axis, act
on T cells to reinstate their antitumor activity. An alternative, and possibly more powerful …

Delivery of mitoxantrone using a plant virus-based nanoparticle for the treatment of glioblastomas

P Lam, RD Lin, NF Steinmetz - Journal of Materials Chemistry B, 2018 - pubs.rsc.org
Mitoxantrone (MTO), an antineoplastic chemotherapeutic, has potent activity against the
most common and aggressive type of primary brain tumor, glioblastoma multiforme (GBM) …

Endosomal toll‐like receptors play a key role in activation of primary human monocytes by cowpea mosaic virus

MM Albakri, FA Veliz, SN Fiering, NF Steinmetz… - …, 2020 - Wiley Online Library
The plant virus, cowpea mosaic virus (CPMV), has demonstrated a remarkable capacity to
induce anti‐tumour immune responses following direct administration into solid tumours …