Recent rapid biotechnological breakthroughs have led to the identification of complex and
unique molecular features that drive malignancies. Precision medicine has exploited next …

Cancer immunotherapy is a validated and critically important approach for treating patients
with cancer. Given the vast research and clinical investigation efforts dedicated to advancing …

Purpose: While various studies have highlighted the prognostic significance of pathologic
complete response (pCR) after neoadjuvant chemotherapy (NAT), the impact of additional …

Importance Approximately 25% of patients with early-stage breast cancer who receive (neo)
adjuvant chemotherapy experience a recurrence within 5 years. Improvements in therapy …

The combination of PD-L1 inhibitor durvalumab and PARP inhibitor olaparib added to
standard paclitaxel neoadjuvant chemotherapy (durvalumab/olaparib/paclitaxel [DOP]) was …

Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

9.128 (Jones and Bartlett Publishers, 2006). 6. Storch, M. et al. BASIC: a new biopart
assembly standard for idempotent cloning provides accurate, singletier DNA assembly for …

There is broad interest in improved methods to generate robust evidence regarding best
practice, especially in settings where patient conditions are heterogenous and require …

Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome.
Understanding of the complex pathways involved in lung injury pathogenesis, resolution …

Background Master protocols, classified as basket trials, umbrella trials, and platform trials,
are novel designs that investigate multiple hypotheses through concurrent sub-studies (eg …