Clinical development of new drug–radiotherapy combinations

RA Sharma, R Plummer, JK Stock… - Nature reviews Clinical …, 2016 - nature.com
In countries with the best cancer outcomes, approximately 60% of patients receive
radiotherapy as part of their treatment, which is one of the most cost-effective cancer …

A roadmap to clinical trials for FLASH

PA Taylor, JM Moran, DA Jaffray… - Medical …, 2022 - Wiley Online Library
While FLASH radiation therapy is inspiring enthusiasm to transform the field, it is neither new
nor well understood with respect to the radiobiological mechanisms. As FLASH clinical trials …

[HTML][HTML] Report dose-to-medium in clinical trials where available; a consensus from the Global Harmonisation Group to maximize consistency

SF Kry, J Lye, CH Clark, N Andratschke… - Radiotherapy and …, 2021 - Elsevier
Purpose To promote consistency in clinical trials by recommending a uniform framework as
it relates to radiation transport and dose calculation in water versus in medium. Methods The …

Radiotherapy dosimetry audit: three decades of improving standards and accuracy in UK clinical practice and trials

CH Clark, EGA Aird, S Bolton, EA Miles… - The British journal of …, 2015 - academic.oup.com
Dosimetry audit plays an important role in the development and safety of radiotherapy.
National and large scale audits are able to set, maintain and improve standards, as well as …

[HTML][HTML] Reirradiation of locally recurrent rectal cancer: a systematic review

MG Guren, C Undseth, BL Rekstad… - Radiotherapy and …, 2014 - Elsevier
Background: Many patients with rectal cancer receive radiotherapy as a component of
primary multimodality treatment. Although local recurrence is infrequent, reirradiation may …

[HTML][HTML] QUARTET: a SIOP Europe project for quality and excellence in radiotherapy and imaging for children and adolescents with cancer

SM Kelly, R Effeney, MN Gaze… - European Journal of …, 2022 - Elsevier
Abstract The European Society for Paediatric Oncology (SIOPE) Radiation Oncology
Working Group presents the QUARTET Project: a centralised quality assurance programme …

[HTML][HTML] Creating a data exchange strategy for radiotherapy research: towards federated databases and anonymised public datasets

T Skripcak, C Belka, W Bosch, C Brink… - Radiotherapy and …, 2014 - Elsevier
Disconnected cancer research data management and lack of information exchange about
planned and ongoing research are complicating the utilisation of internationally collected …

A systematic review of contouring guidelines in radiation oncology: Analysis of frequency, methodology, and delivery of consensus recommendations

D Lin, K Lapen, MV Sherer, J Kantor, Z Zhang… - International Journal of …, 2020 - Elsevier
Purpose Clinical trials have described variation in radiation therapy plan quality, of which
contour delineation is a key component, and linked this to inferior patient outcomes. In …

[HTML][HTML] Adoption of respiratory motion management in radiation therapy

A Burton, S Beveridge, N Hardcastle, J Lye… - Physics and Imaging in …, 2022 - Elsevier
Background and Purpose A survey on the patterns of practice of respiratory motion
management (MM) was distributed to 111 radiation therapy facilities to inform the …

Impact of deviations in target volume delineation–time for a new RTQA approach?

S Cox, A Cleves, E Clementel, E Miles… - Radiotherapy and …, 2019 - Elsevier
The international radiotherapy community has recognised that non-adherence to RT
protocols can influence trial endpoints. However this conclusion is based on studies …