Colorectal cancer is the third most common cancer worldwide with a high mortality rate at
the advanced stages. However, colorectal cancer is not a single type of tumor; its …

Metastatic colorectal carcinoma (mCRC) is a heterogeneous disease with differing
outcomes and clinical responses and poor prognosis. CRCs can be characterised by their …

This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)
for Colon Cancer focuses on systemic therapy options for the treatment of metastatic …

Importance Metastatic colorectal cancer (mCRC) is heterogeneous, and primary tumors
arising from different regions of the colon are clinically and molecularly distinct. Objective To …

Background Retrospective subgroup analyses suggest that primary tumour location (PTL)
has a prognostic importance and relates to response to targeted therapy. Methods We …

Background: Colorectal cancer (CRC) is one of the most common cancers all over the world,
but its epidemiology is obviously different in various regions. Methods: The treatment of CRC …

Purpose: Mutations in KRAS are considered to be the main drivers of acquired resistance to
epidermal growth factor receptor (EGFR) blockade in patients with metastatic colorectal …

背景近年来越来越多的临床研究证实, 晚期结直肠癌的肿瘤部位, 临床病理特征影响患者的预后
及靶向药物的治疗疗效. 但是对于已行结直肠癌根治性切除术的患者, 不同肿瘤部位是否对其 …

Background The prognostic nutritional index (PNI) has been widely applied for predicting
survival outcomes of patients with various malignant tumors. Although a low PNI predicts …

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. CRC develops as a
consequence of genomic instability, characterized by various genetic and epigenetic …