HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

Background Although constipation can be a chronic and severe problem, it is largely treated
empirically. Evidence for the efficacy of some of the older laxatives from well‐designed trials …

Background In this 12-week trial, we aimed to determine the efficacy of prucalopride, a
selective, high-affinity 5-hydroxytryptamine4 receptor agonist, in patients with severe chronic …

Abstract Serotonin (5-hydroxytryptamine; 5-HT) is best known as a neurotransmitter critical
for central nervous system (CNS) development and function. 95% of the body's serotonin …

BACKGROUND & AIMS: 5-hydroxytryptamine receptor (5-HT4R) agonists promote
gastrointestinal motility and attenuate visceral pain, but concerns about adverse reactions …

Background The nonselective 5‐HT 4 receptor agonists, cisapride and tegaserod have been
associated with cardiovascular adverse events (AEs). Aim To perform a systematic review of …

Background Chronic constipation may result in disabling symptoms, is often unsatisfactorily
treated by laxatives and negatively impacts quality of life (QoL). Aim A randomized, double …

Objective: To determine the efficacy, impact on quality of life (QOL) and safety of
prucalopride, a selective, high-affinity 5-HT4 receptor agonist, in patients with chronic …

Objective To determine the efficacy of acotiamide, an acetylcholinesterase inhibitor, in
patients with functional dyspepsia (FD) in a 4-week trial Methods A multicentre, randomised …