The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Meiosis is the basis of sexual reproduction. In female mammals, meiosis of oocytes starts
before birth and sustains at the dictyate stage of meiotic prophase I before gonadotropins …

In mammals, translational control plays critical roles during oocyte-to-embryo transition
(OET) when transcription ceases. However, the underlying regulatory mechanisms remain …

Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Oogenesis is a complex process regulated by a vast number of intra-and extra-ovarian
factors. Oogonia, which originate from primordial germ cells, proliferate by mitosis and form …

Abstract Poly (A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in
the oocyte-to-embryo transition (OET). Nothing is known about poly (A) tail dynamics during …

Translation regulation is critical for early mammalian embryonic development. However,
previous studies had been restricted to bulk measurements, precluding precise …

Fertilization triggers a complex cellular programme that transforms two highly specialized
meiotic germ cells, the oocyte and the sperm, into a totipotent mitotic embryo. Linkages …

The human genome encodes tens of thousands circular RNAs (circRNAs) with mostly
unknown functions. Circular RNAs require internal ribosome entry sites (IRES) if they are to …