The introduction of high-resolution time lapse imaging and molecular biological tools has
changed dramatically the rate of progress towards the understanding of the complex …

Neurexins and neuroligins are emerging as central organizing molecules for excitatory
glutamatergic and inhibitory GABAergic synapses in mammalian brain. They function as cell …

Many cell adhesion molecules are localized at synaptic sites in neuronal axons and
dendrites. These molecules bridge pre-and postsynaptic specializations but do far more …

Chemical synapses are asymmetric intercellular junctions that mediate synaptic
transmission. Synaptic junctions are organized by trans-synaptic cell adhesion molecules …

We identify the leucine-rich repeat transmembrane protein LRRTM2 as a key regulator of
excitatory synapse development and function. LRRTM2 localizes to excitatory synapses in …

Delineating the molecular basis of synapse development is crucial for understanding brain
function. Cocultures of neurons with transfected fibroblasts have demonstrated the synapse …

The mammalian central nervous system (CNS) requires the proper formation of exquisitely
precise circuits to function correctly. These neuronal circuits are assembled during …

A number of synaptogenic factors induce presynaptic or postsynaptic differentiation when
presented to axons or dendrites. Many such factors participate in bidirectional trans-synaptic …

MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors,
adhesion proteins, and various signaling molecules. These complexes evolved prior to the …

The balance between excitatory and inhibitory synaptic inputs, which is governed by
multiple synapse organizers, controls neural circuit functions and behaviors. Slit-and Trk-like …