The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

Few studies have focused on the connection between glymphatic dysfunction and cerebral
small vessel disease (CSVD), partially due to the lack of non-invasive methods to measure …

As the brain transitions from wakefulness to sleep, processing of external information
diminishes while restorative processes, such as glymphatic removal of waste products, are …

Background and Objectives The glymphatic system, which is robustly enabled during some
stages of sleep, is a fluid-transport pathway that clears cerebral waste products. Most …

Current theories of the glymphatic system (GS) hypothesize that it relies on cerebrospinal
fluid (CSF) circulation to disseminate growth factors and remove metabolic waste from the …

In recent years, the existence of a mass transport system in the brain via cerebrospinal fluid
(CSF) or interstitial fluid (ISF) has been suggested by many studies. The glymphatic system …

Sleep is ubiquitous and essential, but its mechanisms remain unclear. Studies in animals
and humans have provided insights of sleep at vastly different spatiotemporal scales …

Normal physiologic function of organs requires a circulation of interstitial fluid to deliver
nutrients and clear cellular waste products. Lymphatic vessels serve as collectors of this fluid …

The choroid plexus (ChP) is part of the blood‐cerebrospinal fluid barrier, regulating brain
homeostasis and the brain's response to peripheral events. Its upregulation and …