Insights into the molecular mechanisms of polycystic kidney diseases
VY Vasileva, RF Sultanova, AV Sudarikova… - Frontiers in …, 2021 - frontiersin.org
Autosomal dominant (AD) and autosomal recessive (AR) polycystic kidney diseases (PKD)
are severe multisystem genetic disorders characterized with formation and uncontrolled …
are severe multisystem genetic disorders characterized with formation and uncontrolled …
Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
M Liu, C Zhang, X Gong, T Zhang, MM Lian, EGY Chew… - Cell Stem Cell, 2024 - cell.com
Human pluripotent stem cell-derived kidney organoids offer unprecedented opportunities for
studying polycystic kidney disease (PKD), which still has no effective cure. Here, we …
studying polycystic kidney disease (PKD), which still has no effective cure. Here, we …
In silico screening and molecular docking study of compounds from Pedalium murex L. with Vasopressin2 receptor target for Autosomal Dominant Polycystic Kidney …
Background Autosomal dominant polycystic kidney disease (ADPKD) is frequently inherited
disease. The medicinal plant Pedalium murex (P. murex) Linn, that has anti-inflammatory …
disease. The medicinal plant Pedalium murex (P. murex) Linn, that has anti-inflammatory …
Rapidly Progressing to ESRD in an Individual with Coexisting ADPKD and Masked Klinefelter and Gitelman Syndromes
R Peces, C Peces, R Mena, E Cuesta… - Genes, 2022 - mdpi.com
Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenetic
hereditary renal disease, promoting end-stage renal disease (ESRD). Klinefelter syndrome …
hereditary renal disease, promoting end-stage renal disease (ESRD). Klinefelter syndrome …
Sex-dependent effects of Nephron Ift88 disruption on BP, renal function, and cystogenesis
C Hu, J Lakshmipathi, E Binning… - Journal of the …, 2021 - journals.lww.com
Background Primary cilia regulation of renal function and BP in health and disease is
incompletely understood. This study investigated the effect of nephron ciliary loss on renal …
incompletely understood. This study investigated the effect of nephron ciliary loss on renal …
Profiling renal sodium transporters in mice with nephron Ift88 disruption: Association with sex, cysts, and blood pressure
C Hu, J Lakshmipathi, D Stuart… - Physiological …, 2022 - Wiley Online Library
Loss of nephron primary cilia due to disruption of the Ift88 gene results in sex‐and age‐
specific phenotypes involving renal cystogenesis, blood pressure (BP) and urinary Na+ …
specific phenotypes involving renal cystogenesis, blood pressure (BP) and urinary Na+ …
Modelling genetic polycystic kidney disease using human pluripotent stem cell-derived kidney organoids
M Liu - 2023 - dr.ntu.edu.sg
Polycystic kidney disease (PKD) is an inherited disorder characterized by progressive
expansion of fluid-filled cysts in the kidney. Autosomal dominant polycystic kidney disease …
expansion of fluid-filled cysts in the kidney. Autosomal dominant polycystic kidney disease …