Nowadays, a large population around the world, especially the elderly, suffers from
neurological inflammatory and degenerative disorders/diseases. Current drug delivery …

The negative surface charge of brain microvessel endothelial cells is derived from the
special composition of their membrane lipids and the thick endothelial surface glycocalyx …

Background During the last decade nanoparticles have gained attention as promising drug
delivery agents that can transport through the blood brain barrier. Recently, several studies …

Disseminated tumors are poorly accessible to nanoscale drug delivery systems because of
the vascular barrier, which attenuates extravasation at the tumor site. We investigated P …

The blood–brain barrier (BBB) is a major obstacle for drug delivery to the brain. To seek for
in vitro BBB models that are more accessible than animals for investigating drug transport …

Nanoparticle tumor accumulation relies on a key mechanism, the enhanced permeability
and retention (EPR) effect, but it remains challenging to decipher the exact impact of the …

Maintaining blood-brain barrier integrity and minimizing neuronal injury are critical
components of any therapeutic intervention following ischemic stroke. However, a low level …

The blood-brain barrier is a unique cell-based restrictive barrier that prevents the entry of
many substances, including most therapeutics, into the central nervous system. A wide …

The highly secure blood–brain barrier (BBB) restricts drug access to the brain, limiting the
molecular toolkit for treating central nervous system (CNS) diseases to small, lipophilic …

Transport of PEGylated silica nanoparticles (PSiNPs) with diameters of 100, 50, and 25 nm
across the blood–brain barrier (BBB) was evaluated using an in vitro BBB model based on …