Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

Synaptic vesicle docking, priming, and fusion at active zones are orchestrated by a complex
molecular machinery. We employed hippocampal organotypic slice cultures from mice …

▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

Summary α-synuclein and cysteine-string protein-α (CSPα) are abundant synaptic vesicle
proteins independently linked to neurodegeneration. Dominantly inherited mutations in α …

The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal
precision and maintains a high level of neurotransmitter release. However, the molecular …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are now
generally accepted to be the major players in the final stage of the docking and the …

Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While …

The maturation of young neurons is regulated by complex mechanisms and dysregulation of
this process is frequently found in neurodevepmental disorders. MicroRNAs have been …