Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

Subtypes of preeclampsia: recognition and determining clinical usefulness

JM Roberts, JW Rich-Edwards, TF McElrath… - …, 2021 - Am Heart Assoc
The concept that preeclampsia is a multisystemic syndrome is appreciated in both research
and clinical care. Our understanding of pathophysiology recognizes the role of inflammation …

Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring

R Fox, J Kitt, P Leeson, CYL Aye… - Journal of clinical …, 2019 - mdpi.com
Hypertensive disorders of pregnancy affect up to 10% of pregnancies worldwide, which
includes the 3%–5% of all pregnancies complicated by preeclampsia. Preeclampsia is …

Pathophysiology of placental-derived fetal growth restriction

GJ Burton, E Jauniaux - American journal of obstetrics and gynecology, 2018 - Elsevier
Placental-related fetal growth restriction arises primarily due to deficient remodeling of the
uterine spiral arteries supplying the placenta during early pregnancy. The resultant …

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

V Steinthorsdottir, R McGinnis, NO Williams… - Nature …, 2020 - nature.com
Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal
health. In genome-wide association meta-analysis of European and Central Asian mothers …

Preeclampsia: updates in pathogenesis, definitions, and guidelines

E Phipps, D Prasanna, W Brima… - Clinical Journal of the …, 2016 - journals.lww.com
Preeclampsia is becoming an increasingly common diagnosis in the developed world and
remains a high cause of maternal and fetal morbidity and mortality in the developing world …

[HTML][HTML] Oxidative stress in placental pathology

MH Schoots, SJ Gordijn, SA Scherjon, H van Goor… - Placenta, 2018 - Elsevier
The most important function of the placenta is the exchange of nutrients and oxygen
between a mother and her fetus. To establish a healthy functioning placenta, placentation …

Preeclampsia: pathogenesis, prevention, and long-term complications

B Jim, SA Karumanchi - Seminars in nephrology, 2017 - Elsevier
Preeclampsia continues to afflict 5% to 8% of all pregnancies throughout the world and is
associated with significant morbidity and mortality to the mother and the fetus. Although the …

The biology of ergothioneine, an antioxidant nutraceutical

I Borodina, LC Kenny, CM McCarthy… - Nutrition Research …, 2020 - cambridge.org
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …