Cancer stem cells: advances in knowledge and implications for cancer therapy

X Chu, W Tian, J Ning, G Xiao, Y Zhou… - … and Targeted Therapy, 2024 - nature.com
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

T Tamura, M Kawano, I Hamachi - Chemical Reviews, 2025 - ACS Publications
The term “undruggable” refers to proteins or other biological targets that have been
historically challenging to target with conventional drugs or therapeutic strategies because …

Engineered stem cell-based strategy: A new paradigm of next-generation stem cell product in regenerative medicine

H Han, BT Chen, Y Liu, Y Wang, L Xing, H Wang… - Journal of Controlled …, 2024 - Elsevier
Stem cells have garnered significant attention in regenerative medicine owing to their
abilities of multi-directional differentiation and self-renewal. Despite these encouraging …

Biomarkers and targeted therapy for cancer stem cells

Y Liu, H Wang - Trends in Pharmacological Sciences, 2024 - cell.com
Cancer stem cells (CSCs) are a small subpopulation of cancer cells with capabilities of self-
renewal, differentiation, and tumorigenicity, and play a critical role in driving tumor …

Bioorthogonal reaction-mediated photosensitizer–peptide conjugate anchoring on cell membranes for enhanced photodynamic therapy

B Hu, C Ji, Z Zhou, X Xu, L Wang, T Cao… - Biomaterials …, 2025 - pubs.rsc.org
Photodynamic therapy (PDT), utilizing a photosensitizer (PS) to induce tumor cell death, is
an effective modality for cancer treatment. PS–peptide conjugates have recently …

High-throughput and multimodal profiling of antigen-specific T cells with a droplet-based cell-cell interaction screening platform

S Wang, Y Zhou, K Ding, ZQ Ding, W Zhang… - Biosensors and …, 2025 - Elsevier
Identifying antigen-specific T cells from tumor-infiltrating lymphocytes is essential for
designing effective T cell immunotherapies. Traditional methods can detect antigen-specific …

[HTML][HTML] Primary adipocytes as targetable drug depot to prevent post-surgical cancer recurrence

Y Bo, Y Wang, J Han, R Bhatta, Y Liu, D Baskaran… - Materials Today Bio, 2024 - Elsevier
Surgery followed by adjuvant chemotherapy or radiation therapy remains the mainstream
treatment for breast cancer in the clinic. However, cancer recurrence post surgery is still …

[PDF][PDF] Materials Today Bio

C Jo, J Zhang, JM Tam, GM Church, AS Khalil, D Segre… - bu.edu
Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …