Astrocyte senescence: evidence and significance

J Cohen, C Torres - Aging cell, 2019 - Wiley Online Library
Astrocytes participate in numerous aspects of central nervous system (CNS) physiology
ranging from ion balance to metabolism, and disruption of their physiological roles can …

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

A Verkhratsky, M Augusto-Oliveira, A Pivoriūnas… - … -European Journal of …, 2021 - Springer
Astroglia represent a class of heterogeneous, in form and function, cells known as
astrocytes, which provide for homoeostasis and defence of the central nervous system …

[18F]FDG PET signal is driven by astroglial glutamate transport

ER Zimmer, MJ Parent, DG Souza, A Leuzy… - Nature …, 2017 - nature.com
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here
we provide positron emission tomography evidence that activation of astrocytic glutamate …

TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation

DM Norden, AM Fenn, A Dugan, JP Godbout - Glia, 2014 - Wiley Online Library
While there clearly is an intimate relationship between astrocytes and microglia, few studies
have examined these potentially dynamic interactions. In this study, cytokine‐mediated …

Astrocyte culture models: Molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells

F Galland, M Seady, J Taday, SS Smaili… - Neurochemistry …, 2019 - Elsevier
The understanding of the physiology of astrocytes and their role in brain function progresses
continuously. Primary astrocyte culture is an alternative method to study these cells in an …

Hippocampal astrocyte cultures from adult and aged rats reproduce changes in glial functionality observed in the aging brain

B Bellaver, DG Souza, DO Souza… - Molecular …, 2017 - Springer
Astrocytes are dynamic cells that maintain brain homeostasis, regulate neurotransmitter
systems, and process synaptic information, energy metabolism, antioxidant defenses, and …

[HTML][HTML] Resveratrol increases antioxidant defenses and decreases proinflammatory cytokines in hippocampal astrocyte cultures from newborn, adult and aged Wistar …

B Bellaver, DG Souza, DO Souza, A Quincozes-Santos - Toxicology in Vitro, 2014 - Elsevier
Astrocytes are responsible for modulating neurotransmitter systems and synaptic information
processing, ionic homeostasis, energy metabolism, maintenance of the blood–brain barrier …

Astrocyte-mediated inflammation in cortical spreading depression

A Ghaemi, L Alizadeh, S Babaei, M Jafarian… - …, 2018 - journals.sagepub.com
Background Cortical spreading depression (CSD) related diseases such as migraine,
cerebrovascular diseases, and epilepsy have been associated with reactive astrocytosis, yet …

Amyloid-β and astrocytes interplay in amyloid-β related disorders

YS Batarseh, QV Duong, YM Mousa… - International journal of …, 2016 - mdpi.com
Amyloid-β (Aβ) pathology is known to promote chronic inflammatory responses in the brain.
It was thought previously that Aβ is only associated with Alzheimer's disease and Down …

Ammonia-induced glial-inflammaging

LD Bobermin, RHA Roppa, CA Gonçalves… - Molecular …, 2020 - Springer
Astrocytes are functionally diverse glial cells that maintain blood-brain barrier (BBB)
integrity, provide metabolic and trophic support, and react to pathogens or harmful stimuli …