Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

Esophageal squamous-cell carcinoma (ESCC) develops through multistage epithelial
cancer formation, ie, from normal epithelium, low-and high-grade intraepithelial neoplasia to …

The extent to which cells in normal tissues accumulate mutations throughout life is poorly
understood. Some mutant cells expand into clones that can be detected by genome …

Clonal expansion in aged normal tissues has been implicated in the development of cancer.
However, the chronology and risk dependence of the expansion are poorly understood …

Gene fusions represent an important class of somatic alterations in cancer. We
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …

We evaluated ancestry effects on mutation rates, DNA methylation, and mRNA and miRNA
expression among 10,678 patients across 33 cancer types from The Cancer Genome Atlas …

Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that
is not fully explained by known lifestyle and environmental risk factors. It has been …

Esophageal squamous cell carcinoma (ESCC) is a poor-prognosis cancer type with limited
understanding of its molecular etiology. Using 508 ESCC genomes, we identified five novel …

Upper urinary tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Its
molecular pathogenesis, however, is poorly understood, with no useful biomarkers available …