Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

The nuclear import of proteins through nuclear pore complexes (NPCs) illustrates how a
complex biological function can be generated by a spatially and temporally organized cycle …

Karyopherinβ (Kapβ) proteins bind nuclear localization and export signals (NLSs and NESs)
to mediate nucleocytoplasmic trafficking, a process regulated by Ran GTPase through its …

In eukaryotic cells, segregation of DNA replication and RNA biogenesis in the nucleus and
protein synthesis in the cytoplasm poses the requirement of transporting thousands of …

CRM1 mediates nuclear export of numerous unrelated cargoes, which may carry a short
leucine-rich nuclear export signal or export signatures that include folded domains. How …

The maintenance of genome integrity is essential for any organism survival and for the
inheritance of traits to offspring. To the purpose, cells have developed a complex DNA repair …

Nuclear export is an essential eukaryotic activity. It proceeds through nuclear pore
complexes (NPCs) and is mediated by soluble receptors that shuttle between nucleus and …

Recent structural work on nuclear transport factors of the importin-β superfamily of
karyopherins has shown that these proteins are superhelices of HEAT repeats that are able …

The p53 tumor suppressor protein regulates many genes that can determine different
cellular outcomes such as growth arrest or cell death. Promoter-selective transactivation by …