The valproic acid-induced rodent model of autism

C Nicolini, M Fahnestock - Experimental neurology, 2018 - Elsevier
Autism is a lifelong neurodevelopmental disorder characterized by impairments in social
communication and interaction and by repetitive patterns of behavior, interests and activities …

Histone deacetylases inhibitors in neurodegenerative diseases, neuroprotection and neuronal differentiation

S Shukla, BL Tekwani - Frontiers in pharmacology, 2020 - frontiersin.org
Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid

S Kataoka, K Takuma, Y Hara, Y Maeda… - International journal …, 2013 - academic.oup.com
Maternal use of valproic acid (VPA) during pregnancy has been implicated in the aetiology
of autism spectrum disorders in children, and rodents prenatally exposed to VPA showed …

Three decades of valproate: a current model for studying autism Spectrum disorder

D Zarate-Lopez, AL Torres-Chávez… - Current …, 2024 - benthamdirect.com
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with increased
prevalence and incidence in recent decades. Its etiology remains largely unclear, but it …

Human forebrain organoids reveal connections between valproic acid exposure and autism risk

Q Meng, W Zhang, X Wang, C Jiao, S Xu, C Liu… - Translational …, 2022 - nature.com
Valproic acid (VPA) exposure as an environmental factor that confers risk of autism spectrum
disorder (ASD), its functional mechanisms in the human brain remain unclear since relevant …

Transcutaneous implantation of valproic acid-encapsulated dissolving microneedles induces hair regrowth

SF Lahiji, SH Seo, S Kim, M Dangol, J Shim, CG Li… - Biomaterials, 2018 - Elsevier
The interest in alternative material systems and delivery methods for treatment of
androgenetic alopecia has been increasing in the recent decades. Topical application of …

Neonatal oxytocin treatment ameliorates autistic-like behaviors and oxytocin deficiency in valproic acid-induced rat model of autism

YC Dai, HF Zhang, M Schön, TM Böckers… - Frontiers in cellular …, 2018 - frontiersin.org
Autism spectrum disorder (ASD) is characterized by impaired social communication and
repetitive/stereotyped behaviors. The neuropeptide oxytocin (OXT) plays a critical role in …

Duloxetine ameliorates valproic acid‐induced hyperactivity, anxiety‐like behavior, and social interaction deficits in zebrafish

TP Joseph, F Zhou, LY Sai, H Chen, SL Lin… - Autism …, 2022 - Wiley Online Library
Syndromic autism spectrum disorders (ASDs) are characterized by impaired social
communication and repetitive/stereotyped behaviors. Currently available therapeutic agents …

The neurotrophic and neuroprotective effects of psychotropic agents

J Hunsberger, DR Austin, ID Henter… - Dialogues in clinical …, 2009 - Taylor & Francis
Accumulating evidence suggests that psychotropic agents such as mood stabilizers,
antidepressants, and antipsychotics realize their neurotrophic/neuroprotective effects by …

Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice

RX Moldrich, G Leanage, D She, E Dolan-Evans… - Behavioural brain …, 2013 - Elsevier
Exposure to sodium valproate (VPA) in utero increases the risk of language impairment and
a diagnosis of autism spectrum disorder (ASD). Mice exposed to VPA while in utero have …