As the single cell lining of the heart and all blood vessels, the vascular endothelium serves a
critical role in maintaining homeostasis via control of vascular tone, immune cell recruitment …

Purpose Vascular endothelium plays a central role in the pathogenesis of acute and chronic
radiation injuries, yet the mechanisms which promote sustained endothelial dysfunction and …

Rationale: Mesoscopic visualization of the main anatomical structures of the whole kidney in
vivo plays an important role in the pathological diagnosis and exploration of the etiology of …

Recent advances in optical tissue clearing and three-dimensional (3D) fluorescence
microscopy have enabled high resolution in situ imaging of intact tissues. Using simply …

Abstract Three-dimensional (3D) high-resolution large-volume imaging has remained a
challenge. Translational rapid ultraviolet-excited sectioning tomography (TRUST) achieves …

Rapid multicolor three-dimensional (3D) imaging for centimeter-scale specimens with
subcellular resolution remains a challenging but captivating scientific pursuit. Here, we …

Though angiogenesis has been investigated in depth, vascular regression and rarefaction
remain poorly understood. Regression of renal vasculature accompanies many pathological …

Currently, there are no biomarkers to predict lethal lung injury by radiation. Since it is not
ethical to irradiate humans, animal models must be used to identify biomarkers. Injury to the …

Rapid multicolor three-dimensional (3D) imaging for centimeter-scale specimens with
subcellular resolution remains a challenging but captivating scientific pursuit. Here, we …

Abstract Currently, chemotherapy, radiotherapy, surgery, and local ablative therapies are the
primary techniques for cancer treatment. However, often local ablative methods just delay …