Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

Abstract Development is a dynamic process that involves interplay between genes and the
environment. In mammals, the quality of the postnatal environment is shaped by parent …

This review provides a broad overview of the state of research in the genetics of anxiety
disorders (AD). Genetic epidemiological studies report a moderate level of familial …

Depression is a devastating psychiatric disorder caused by a combination of genetic
predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular …

Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate
anxiety and fear learning. These CeA CRF neurons release GABA and several …

Stressful events in an early postnatal period have critical implications for the individual's life
and can increase later risk for psychiatric disorders. The aim of this study was to investigate …

Anxiety disorders are highly prevalent psychiatric disorders often comorbid with depression
and substance abuse. Twin studies have shown that anxiety disorders are moderately …

Major depressive disorder (MDD) is a prevalent psychiatric disorder that brings great harm
and burden to both patients and society. This study aimed to examine the effects of whole …

Epigenetic mechanisms such as DNA methylation are part of an emerging story on how
early-life experiences can alter behavioral trajectories and lead to the development of …

Cancer is considered as one of the main causes of human deaths globally. Despite the
recent progresses in therapeutic modalities, there is still a high rate of mortality among …