Inhibitors targeting the PWWP domain-containing proteins
Y Huang, B Li, Z Wu, K Liu, J Min - European Journal of Medicinal …, 2024 - Elsevier
ABSTRACT PWWP domain-containing proteins play a pivotal role in chromatin-mediated
biological processes, and their aberrant regulation is linked to various human diseases …
biological processes, and their aberrant regulation is linked to various human diseases …
Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors
C Yang, B Li, Z Feng, H Li, H Yang… - Journal of medicinal …, 2024 - ACS Publications
Both G9a and NSD2 have been recognized as promising therapeutic targets for cancer
treatment. However, G9a inhibitors only showed moderate inhibitory activity against solid …
treatment. However, G9a inhibitors only showed moderate inhibitory activity against solid …
Discovery of a highly potent and selective inhibitor targeting protein lysine methyltransferase NSD2
J Wei, Q Shi, B Li, H Yang, L Liu, R Zhou… - Journal of Medicinal …, 2024 - ACS Publications
The histone lysine methyltransferase NSD2 has been recognized as an attractive target for
cancer treatment, due to the functional implication of its dysregulation in the initiation and …
cancer treatment, due to the functional implication of its dysregulation in the initiation and …