Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky
DNA lesions such as those formed by UV light, environmental mutagens, and some cancer …

DNA is one of the prime molecules, and its stability is of utmost importance for proper
functioning and existence of all living systems. Genotoxic chemicals and radiations exert …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

Numerous agents of endogenous and exogenous origin damage DNA in our genome.
There are several DNA‐repair pathways that recognize lesions in DNA and remove them …

Nucleotide excision repair (NER) requires the coordinated sequential assembly and actions
of the involved proteins at sites of DNA damage. Following damage recognition, dual …

Publisher Summary DNA damage is a common occurrence that compromises the functional
integrity of DNA. It is not surprising then that cells have multiple mechanisms for coping with …

During human nucleotide excision repair, damage is recognized, two incisions are made
flanking a DNA lesion, and residues are replaced by repair synthesis. A set of proteins …

Upon gene activation, we found that RNA polymerase II transcription machinery assembles
sequentially with the nucleotide excision repair (NER) factors at the promoter. This …

Nucleotide excision repair (NER) is found throughout nature, in eubacteria, eukaryotes and
archaea. In human cells it is the main pathway for the removal of damage caused by UV …

Nucleotide excision repair (NER) is a DNA repair pathway that is responsible for removing a
variety of lesions caused by harmful UV light, chemical carcinogens, and environmental …