[HTML][HTML] Minimally Modified HIV-1 Infection of Macaques: Development, Utility, and Limitations of Current Models
Nonhuman primate (NHP) studies that utilize simian immunodeficiency virus (SIV) to model
human immunodeficiency virus (HIV-1) infection have proven to be powerful, highly …
human immunodeficiency virus (HIV-1) infection have proven to be powerful, highly …
[HTML][HTML] Effect of metabolic status on response to SIV infection and antiretroviral therapy in nonhuman primates
GM Webb, KA Sauter, D Takahashi, M Kirigiti… - JCI …, 2024 - pmc.ncbi.nlm.nih.gov
Current antiretroviral therapy (ART) regimens efficiently limit HIV replication, thereby
improving the life expectancy of people living with HIV; however, they also cause metabolic …
improving the life expectancy of people living with HIV; however, they also cause metabolic …
Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence
B Varco-Merth, M Chaunzwa, DM Duell… - PLoS …, 2024 - journals.plos.org
Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell
compartment of people living with HIV remains a major barrier to HIV cure. Here, we …
compartment of people living with HIV remains a major barrier to HIV cure. Here, we …
Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy
VA Klenchin, NM Clark, NK Keles, S Capuano 3rd… - bioRxiv, 2024 - biorxiv.org
An alternative to lifelong antiretroviral therapy (ART) is needed to achieve durable control of
HIV-1. Here we show that adeno-associated virus (AAV)-delivery of two rhesus macaque …
HIV-1. Here we show that adeno-associated virus (AAV)-delivery of two rhesus macaque …
Super antibodies–bear in mind
SR Hosein - catie.ca
As mentioned earlier in this issue of TreatmentUpdate, there are several super antibodies
(also known as broadly neutralizing antibodies, or bNAb) in development. These are …
(also known as broadly neutralizing antibodies, or bNAb) in development. These are …