The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a
wide array of developmental processes. Over 240 HLH proteins have been identified to date …

Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that
contribute to the building of the heart leads to cardiac malformations, which frequently result …

We have isolated a cardiomyogenic cell line (CMG) from murine bone marrow stromal cells.
Stromal cells were immortalized, treated with 5-azacytidine, and spontaneously beating cells …

MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …

Gradients of signalling and transcription factors govern many aspects of embryogenesis,
highlighting the need for spatiotemporal control of regulatory protein levels. MicroRNAs are …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

Members of the myocyte enhancer factor–2 (MEF2) family of MADS (MCM1, agamous,
deficiens, serum response factor)–box transcription factors bind an AT–rich DNA sequence …

Previous studies have suggested that the GATA4 transcription factor plays an important role
in regulating mammalian cardiac development. In the studies described in this report we …

How a cell responds to stress is a central problem in cardiovascular biology. Diverse
physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) …

The cues governing cardiac cell-fate decisions, cardiac differentiation, and three-
dimensional morphogenesis are rapidly being elucidated. Several themes are emerging that …