The primary function of the gut is to procure nutrients. Synchronized mechanical activities
underlie nearly all its endeavours. Coordination of mechanical activities depends on …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …

Tissue acidosis is a common feature of many painful conditions. Protons are indeed among
the first factors released by injured tissues, inducing a local pH fall that depolarizes …

Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-
gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs …

Acidosis is a noxious condition associated with inflammation, ischaemia or defective acid
containment. As a consequence, acid sensing has evolved as an important property of …

Since their molecular cloning in the late 90's, Acid-Sensing Ion Channels (ASICs) have been
shown to be involved in many aspects of nociception, both in peripheral and central …

BACKGROUND & AIMS: The transient receptor potential (TRP) channel family includes
transducers of mechanical and chemical stimuli for visceral sensory neurons. TRP ankyrin 1 …

Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

Objective The gut is a major site of contact between immune and sensory systems and
evidence suggests that patients with irritable bowel syndrome (IBS) have immune …