Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
Cytokines and chemokines involved in osteoarthritis pathogenesis
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …
The extracellular matrix as a multitasking player in disease
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
The potential role of synovial cells in the progression and treatment of osteoarthritis
Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …
Intra-articular targeting of nanomaterials for the treatment of osteoarthritis
Osteoarthritis is a prevalent and debilitating disease that involves pathological contributions
from numerous joint tissues and cells. The joint is a challenging arena for drug delivery …
from numerous joint tissues and cells. The joint is a challenging arena for drug delivery …
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to …
H Zhou, X Shen, C Yan, W Xiong, Z Ma, Z Tan… - Stem Cell Research & …, 2022 - Springer
Background Osteoarthritis (OA) is a prevalent degenerative joint disease that not only
significantly impairs the quality of life of middle-aged and elderly individuals but also …
significantly impairs the quality of life of middle-aged and elderly individuals but also …
Inhibition of MMPs and ADAM/ADAMTS
CJ Malemud - Biochemical pharmacology, 2019 - Elsevier
Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …
Extracellular vesicles are integral and functional components of the extracellular matrix
K Rilla, AM Mustonen, UT Arasu, K Härkönen… - Matrix Biology, 2019 - Elsevier
Extracellular vesicles (EV) are small plasma membrane-derived particles released into the
extracellular space by virtually all cell types. Recently, EV have received increased interest …
extracellular space by virtually all cell types. Recently, EV have received increased interest …
[HTML][HTML] Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine
Aging biology is a promising and burgeoning research area that can yield dual-purpose
pathways and protein targets that may impact multiple diseases, while retarding or possibly …
pathways and protein targets that may impact multiple diseases, while retarding or possibly …
Subchondral bone remodelling in osteoarthritis
S Donell - EFORT open reviews, 2019 - eor.bioscientifica.com
Subchondral bone remodelling is an integral part of osteoarthritis and involves the
development of subchondral sclerosis seen on plain imaging, along with osteophyte …
development of subchondral sclerosis seen on plain imaging, along with osteophyte …