Purpose: To review evidence on the diagnostic accuracy of clinical information and imaging
for patients with low back pain in primary care settings. Data Source: MEDLINE search …

Background Previous systematic reviews have reported positive associations between
Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new …

The prevalence of “vertebral endplate signal changes”(VESC) and its association with low
back pain (LBP) varies greatly between studies. This wide range in reported prevalence …

The sequelae of disk degeneration are among the leading causes of functional incapacity in
both sexes and are a common source of chronic disability in the working years. Disk …

In patients with low back pain (LBP) it is only possible to diagnose a small proportion,(
approximately 20%), on a patho-anatomical basis. Therefore, the identification of relevant …

Study Design. Cross-sectional comparison of self-reported low back pain (LBP) symptoms
and Modic findings on magnetic resonance imaging (MRI). Objectives. To investigate …

Background context Magnetic resonance imaging (MRI) has limited diagnostic value for
chronic low back pain because of the unclear relationship between any anatomic …

Study Design. Immunohistochemistry for tumor necrosis factor (TNF) and protein gene
product (PGP) 9.5 in vertebral endplates of patients with discogenic low back pain and …

Two decades following their description, the significance of Modic vertebral endplate and
marrow changes remains a matter of debate. These changes are closely related to the …

Modic changes (MC) are a common phenomenon on magnetic resonance imaging (MRI) in
spinal degenerative diseases and strongly linked with low back pain (LBP). Histology …