Proteins of the signal transducer and activator of transcription (STAT) family mediate cellular
responses to cytokines and growth factors. Aberrant regulation of the STAT3 oncogene …

Signal transducer and activator of transcription 3 (STAT3) plays a critical role in signal
transmission from the plasma membrane to the nucleus, regulating the expression of genes …

Os vegetais superiores são usados com finalidades terapêuticas por todas as culturas. O
Brasil tem a maior biodiversidade do mundo e ocupa a 13 a posição quanto à publicação …

Developing drugs that can effectively block STAT3 activation may serve as one of the most
promising strategy for cancer treatment. Currently, there is no putative STAT3 inhibitor that …

Redox signaling plays a fundamental role in maintaining cell physiological activities. A
deregulation of this balance through oxidative stress or nitrosative stress has been …

In our study, it was applied for the technology of supercritical fluid carbon dioxide extraction
to achieve biological constitutes from a Taiwan native plant, Polygonum cuspidatum. We …

The discovery of effective constituents of traditional Chinese medicine (TCM) is an important
approach in new drug development. Several well-known drugs, such as artemisinin …

Nature is an attractive source of therapeutic and preventive compounds, and with such
chemical diversity found in millions of species of plants, over 60% of currently used …

Background Signal transducer and activator of transcription 3 (STAT3) is an oncogene
constitutively activated in hepatocellular carcinoma (HCC) cells and HCC cancer stem cells …

Objectives Esculetin is a coumarin derivative, which is extracted from the dried barks of
fraxinus chinensis Roxb. Although it is reported esculetin possesses multiple …