ADP-ribosylation is an intricate and versatile posttranslational modification involved in the
regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives …

Nicotinamide adenine dinucleotide (NAD+) serves as a critical cofactor in cellular
metabolism and redox reactions. Bacterial pathways rely on NAD+ participation, where its …

Selective autophagy helps eukaryotes to cope with endogenous dangers or foreign
invaders; its initiation often involves membrane damage. By studying a Salmonella effector …

Despite decades of research on ADP‐ribosyltransferases (ARTs) from the poly (ADP‐ribose)
polymerase (PARP) family, one key aspect of these enzymes–their substrate specificity–has …

ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life.
The system likely originated in bacteria where it functions in inter-and intra-species conflict …

Ubiquitination is essential for numerous eukaryotic cellular processes. Here, we show that
the type III effector CteC from Chromobacterium violaceum functions as an adenosine …

Caspases are evolutionarily conserved cysteine proteases that are essential for regulating
cell death and are involved in multiple development and disease processes, including …

NAD metabolism is essential for all forms of life. Compartmental regulation of NAD+
consumption, especially between the nucleus and the mitochondria, is required for energy …

Nicotinamide adenine dinucleotide (NAD+) is a major cofactor in redox reactions in all life-
forms. A stable level of NAD+ is vital to ensure cellular homeostasis. Some pathogens can …

Dynamic ADP-ribosylation signaling is a crucial pathway that controls fundamental cellular
processes, in particular, the response to cellular stresses such as DNA damage, reactive …