[HTML][HTML] New approaches to understanding the immune response to vaccination and infection
The immune system is a network of specialized cell types and tissues that communicates via
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
Immune and metabolic signatures of COVID-19 revealed by transcriptomics data reuse
The current pandemic of coronavirus disease 19 (COVID-19) has affected millions of
individuals and caused thousands of deaths worldwide. The pathophysiology of the disease …
individuals and caused thousands of deaths worldwide. The pathophysiology of the disease …
[HTML][HTML] Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: Influenza life-cycle and …
R Gasparini, D Amicizia, PL Lai… - Journal of preventive …, 2014 - ncbi.nlm.nih.gov
Compounds with anti-influenza activity: present and future of strategies for the optimal
treatment and management of influenza. Part I: influenza life-cycle and currently available …
treatment and management of influenza. Part I: influenza life-cycle and currently available …
Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity across viruses
Viral infections induce a conserved host response distinct from bacterial infections. We
hypothesized that the conserved response is associated with disease severity and is distinct …
hypothesized that the conserved response is associated with disease severity and is distinct …
Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subject to restriction by
several interferon-inducible host proteins. To identify novel factors that limit replication of the …
several interferon-inducible host proteins. To identify novel factors that limit replication of the …
Interferon lambda signaling in macrophages is necessary for the antiviral response to influenza
RK Mallampalli, J Adair, A Elhance, D Farkas… - Frontiers in …, 2021 - frontiersin.org
Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in
murine models, yet little is known about its molecular regulation and its cognate receptor …
murine models, yet little is known about its molecular regulation and its cognate receptor …
[Retracted] Identifying COVID‐19‐Specific Transcriptomic Biomarkers with Machine Learning Methods
COVID‐19, a severe respiratory disease caused by a new type of coronavirus SARS‐CoV‐
2, has been spreading all over the world. Patients infected with SARS‐CoV‐2 may have no …
2, has been spreading all over the world. Patients infected with SARS‐CoV‐2 may have no …
Landscape of coordinated immune responses to H1N1 challenge in humans
Influenza is a significant cause of morbidity and mortality worldwide. Here we show changes
in the abundance and activation states of more than 50 immune cell subsets in 35 …
in the abundance and activation states of more than 50 immune cell subsets in 35 …
Benchmarking transcriptional host response signatures for infection diagnosis
DG Chawla, A Cappuccio, A Tamminga, SC Sealfon… - Cell Systems, 2022 - cell.com
Identification of host transcriptional response signatures has emerged as a new paradigm
for infection diagnosis. For clinical applications, signatures must robustly detect the …
for infection diagnosis. For clinical applications, signatures must robustly detect the …
KLRD1-expressing natural killer cells predict influenza susceptibility
Background Influenza infects tens of millions of people every year in the USA. Other than
notable risk groups, such as children and the elderly, it is difficult to predict what …
notable risk groups, such as children and the elderly, it is difficult to predict what …