Parasitic protozoa of the phylum Apicomplexa cause a range of human and animal
diseases. Their complex life cycles–often heteroxenous with sexual and asexual phases in …

Plasmodium spp. parasites that cause malaria disease remain a significant global-health
burden. With the spread of parasites resistant to artemisinin combination therapies in …

Apicomplexan parasites secrete contents of the rhoptries, club-shaped organelles in the
apical region, into host cells to permit their invasion and establishment of infection. The …

Tackling relapsing Plasmodium vivax and zoonotic Plasmodium knowlesi infections is
critical to reducing malaria incidence and mortality worldwide. Understanding the biology of …

Intracellular pathogens mobilize host signaling pathways of their host cell to promote their
own survival. Evidence is emerging that signal transduction elements are activated in a …

Abstract Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family found in all
Plasmodium species, but are significantly expanded in P. vivax and closely related …

Plasmodium malaria parasites are obligate intracellular protozoans that use a unique form
of locomotion, termed gliding motility, to move through host tissues and invade cells. The …

Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For
Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric …

Infectious diseases continue to pose a substantial burden on global populations, requiring
innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed …

During the course of the asexual erythrocytic stage of development, Plasmodium spp.
parasites undergo a series of morphological changes and induce alterations in the host cell …