Hydroxyurea is a well-established inhibitor of ribonucleotide reductase that has a long
history of scientific interest and clinical use for the treatment of neoplastic and non …

Background & Aims Alcoholic liver disease (ALD) is a leading cause of liver failure and
mortality. In humans, severe alcoholic hepatitis is associated with key changes to intestinal …

Proteins are not monolithic entities; rather, they can contain multiple domains that mediate
distinct interactions, and their functionality can be regulated through post-translational …

To identify near complete sets of genes required for the cell cycle and cell shape, we have
visually screened a genome-wide gene deletion library of 4843 fission yeast deletion …

Gene duplication is widely believed to facilitate adaptation, but unambiguous evidence for
this hypothesis has been found in only a small number of cases. Although gene duplication …

Motivation Barcode sequencing (bar-seq) is a high-throughput, and cost effective method to
assay large numbers of cell lineages or genotypes in complex cell pools. Because of its …

New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium
tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and …

Alterations in histone modification have been linked to cancer development and
progression. Celastrol, a Chinese herbal compound, shows potent anti-tumor effects through …

High-throughput quantitative DNA sequencing enables the parallel phenotyping of pools of
thousands of mutants. However, the appropriate analytical methods and experimental …

Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important
roles in animal development and human diseases. Molecular understanding of autophagy …