Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …
because of their non-convulsive nature and the large incidence of remittance in early …
Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders
B Santoro, MM Shah - Annual review of pharmacology and …, 2020 - annualreviews.org
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
Ketamine triggers a switch in excitatory neuronal activity across neocortex
The brain can become transiently disconnected from the environment while maintaining
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …
vivid, internally generated experiences. This so-called 'dissociated state'can occur in …
Discrete subicular circuits control generalization of hippocampal seizures
F Fei, X Wang, C Xu, J Shi, Y Gong, H Cheng… - Nature …, 2022 - nature.com
Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …
Cardiac and neuronal HCN channelopathies
I Rivolta, A Binda, A Masi, JC DiFrancesco - Pflügers Archiv-European …, 2020 - Springer
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
The contribution of HCN channelopathies in different epileptic syndromes, mechanisms, modulators, and potential treatment targets: a systematic review
M Kessi, J Peng, H Duan, H He, B Chen… - Frontiers in Molecular …, 2022 - frontiersin.org
Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …
Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets
Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …
medically refractory. The thalamus, with widespread connections throughout the brain, plays …
The hyperpolarization-activated HCN4 channel is important for proper maintenance of oscillatory activity in the thalamocortical system
M Zobeiri, R Chaudhary, A Blaich, M Rottmann… - Cerebral …, 2019 - academic.oup.com
Hyperpolarization-activated cation channels are involved, among other functions, in learning
and memory, control of synaptic transmission and epileptogenesis. The importance of the …
and memory, control of synaptic transmission and epileptogenesis. The importance of the …
[HTML][HTML] HCN channels and absence seizures
Hyperpolarization-activation cyclic nucleotide-gated (HCN) channels were for the first time
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …
implicated in absence seizures (ASs) when an abnormal I h (the current generated by these …
Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice
The causative link between focal cortical malformations (FCMs) and epilepsy is well
accepted, especially among patients with focal cortical dysplasia type II (FCDII) and …
accepted, especially among patients with focal cortical dysplasia type II (FCDII) and …