Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune
modulation, and secondary dissemination to distant sites through a series of mechanisms …

Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease
status provides great prognostic power, but how lymph node metastases should be treated …

Evidence reveals that gastric cancer (GC) is the fifth most common malignancy in humans,
and about 770,000 people die from this cancer yearly. It has been reported that new cases …

A number of case-control studies regarding the association of the polymorphisms in the
programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) genes with …

Suppression of the immune system is intimately linked to the development and progression
of malignancy, and immune modulating treatment options have shown promise in a variety …

Emerging evidence indicates that cancer cells can mimic characteristics of embryonic
development, promoting their development and progression. Cancer cells share features …

Major histocompatibility complex (MHC) class I is a membrane-bound protein complex
expressed on nucleated human cells. MHC class I presents intracellular protein fragments to …

Immune checkpoint proteins, such as programmed cell death receptor 1 (PD-1) and its
ligand (PD-L1), play critical roles in the pathology of chronic inflammatory pathological …

Approximately 30% of human cancers harbor a gain‐in‐function mutation in the RAS gene,
resulting in constitutive activation of the RAS protein to stimulate downstream signaling …