Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer's disease

SP Yu, MQ Jiang, SS Shim, S Pourkhodadad… - Molecular …, 2023 - Springer
Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

[HTML][HTML] Autophagy in Alzheimer's disease pathogenesis: Therapeutic potential and future perspectives

Z Zhang, X Yang, YQ Song, J Tu - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …

Memantine for the treatment of dementia: a review on its current and future applications

J Folch, O Busquets, M Ettcheto… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in
the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …

Alzheimer's disease, β‐amyloid, glutamate, NMDA receptors and memantine–searching for the connections

W Danysz, CG Parsons - British journal of pharmacology, 2012 - Wiley Online Library
β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

Dysfunction of NMDA receptors in Alzheimer's disease

Y Zhang, P Li, J Feng, M Wu - Neurological Sciences, 2016 - Springer
N-methyl-d-aspartate receptors (NMDARs) play a pivotal role in the synaptic transmission
and synaptic plasticity thought to underlie learning and memory. NMDARs activation has …

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non‐human primate model of …

AF Batista, L Forny‐Germano, JR Clarke… - The Journal of …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective
treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics …

Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model

M Kitazawa, D Cheng, MR Tsukamoto… - The Journal of …, 2011 - journals.aai.org
Inflammation is a key pathological hallmark of Alzheimer's disease (AD), although its impact
on disease progression and neurodegeneration remains an area of active investigation …

Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease

CG Parsons, W Danysz, A Dekundy, I Pulte - Neurotoxicity research, 2013 - Springer
This review describes the preclinical mechanisms that may underlie the increased
therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor …

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

TJ Revett, GB Baker, J Jhamandas, S Kar - Journal of Psychiatry and …, 2013 - jpn.ca
Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …

The role of tau in Alzheimer's disease and related disorders

R Medeiros, D Baglietto‐Vargas… - CNS neuroscience & …, 2011 - Wiley Online Library
Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as
neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under …