Z Zhang, X Yang, YQ Song, J Tu - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the most common cause of human dementia. AD is characterized by accumulation of abnormal …
J Folch, O Busquets, M Ettcheto… - Journal of …, 2018 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the presence in the brain of extracellular amyloid-protein (A) and intracellular neurofibrillary tangles …
W Danysz, CG Parsons - British journal of pharmacology, 2012 - Wiley Online Library
β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying Alzheimer's disease (AD), although there is presently lively debate regarding the relative …
Y Zhang, P Li, J Feng, M Wu - Neurological Sciences, 2016 - Springer
N-methyl-d-aspartate receptors (NMDARs) play a pivotal role in the synaptic transmission and synaptic plasticity thought to underlie learning and memory. NMDARs activation has …
AF Batista, L Forny‐Germano, JR Clarke… - The Journal of …, 2018 - Wiley Online Library
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease‐modifying therapeutics …
M Kitazawa, D Cheng, MR Tsukamoto… - The Journal of …, 2011 - journals.aai.org
Inflammation is a key pathological hallmark of Alzheimer's disease (AD), although its impact on disease progression and neurodegeneration remains an area of active investigation …
CG Parsons, W Danysz, A Dekundy, I Pulte - Neurotoxicity research, 2013 - Springer
This review describes the preclinical mechanisms that may underlie the increased therapeutic benefit of combination therapy—with the N-methyl-d-aspartate receptor …
TJ Revett, GB Baker, J Jhamandas, S Kar - Journal of Psychiatry and …, 2013 - jpn.ca
Alzheimer disease is the most prevalent form of dementia globally and is characterized premortem by a gradual memory loss and deterioration of higher cognitive functions and …
R Medeiros, D Baglietto‐Vargas… - CNS neuroscience & …, 2011 - Wiley Online Library
Tau, the microtubule‐associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under …